Photo by The AP

In 2010, Tom Brady broke his own 2007 record for highest TD / INT ratio in a season, while three other quarterbacks also posted top 25 all-time numbers.

Brady threw a total of 36 touchdowns and four interceptions for a TD/INT ratio of 9 - the highest single-season ratio posted by any passer in NFL history (minimum 300 attempts).

During his storied 2007 campaign, he threw for 50 touchdowns and eight interceptions for a TD/INT ratio of 6.25. Brady is the only player to achieve a ratio above six.

In addition to Brady's new record, Josh Freeman, Matt Cassell and Michael Vick posted TD/INT ratios of 3.5 or higher, ranking their seasons among the top 25 in history. Freeman's ratio of 4.2 (25 TD, 6 INT) was 10th highest all time, while Cassell's 3.9 (27 TD, 7 INT) was 13th highest and Vick's 3.5 (26 TD, 6 INT) was 21st.

This is only the second time in history that four players have simultaneously had TD/INT ratios of 3.5 or more in a single season. The first time it happened was 2004, when Peyton Manning (4.9, 49/10), Donovan McNabb (3.9, 31/8), Drew Brees (3.9, 27/7) and Daunte Culpepper (3.5, 39/11) all hit their marks.

Here are the all-time top 25 seasons ranked by TD/INT (minimum 300 attempts):